FSH ELISA from BIOSERV Diagnostics
FSH and LH are gonadotropins from the anterior lobe of the pituitary gland. Like the placentar hormone hCG and like TSH (Thyreoidea stimulating hormone) they are proteohormones of about 30 kD, sharing the same α-subunit. The biological activity of these hormones is determined by the specific β-subunit.
The use of this FSH test for the determination of FSH and LH is indicated for the assessment of menstrual cycle disorders, fertility problems and the assessment of a hormonal substitution during the climacterium. Continuously high FSH and LH values are characteristic for a primary orvarial insufficiency.
With the BIOSERV FSH Serum ELISA human follicle-stimulating hormone (hFSH) is detected in human serum.
The FSH ELISA from BIOSERV is a ready-to-use kit.
To order the test please refer to the BIOSERV catalogue number BS - 85 - 22.
For further information please send us an e-mail: info@bioserv-diagnostics.com
EU registration number
DE/CA80/IVD1686
Detailed information on the hFSH ELISA from BIOSERV Diagnostics
The human Follicle-Stimulating Hormone or Follitropin (hFSH) belongs to the gonadotropins, a group of hormones regulating the sexual functions of the female and the male body. hFSH is a glycoprotein synthetized in the anterior lobe of the pituitary gland and released under the influence of the gonadotropin-releasing-hormone (Gn-RH). It has a molecular weight of 30 kD and consists, like the other two gonadotropins hLH (human Luteinizing Hormone, Lutropin, Interstitial Cell Stimulating Hormone ICSH) and hCG (human Chorionic Gonadotropin) and like hTSH (human Thyreoidea-Stimulating Hormone = human Thyreotropin) of two subunits, called a and b. The a-subunits are identical for all these hormones, the hormonal specificity and the specific immunological properties are due to the b-subunits.
In women hFSH and hLH are responsible for the modificatory changes of the ovaries in the course of the menstrual cycle. In the follicular phase hFSH plays an important role in the maturing of the follicle, the development of the Graaf’s follicle and in the maturing of the egg. hFSH also stimulates the biosynthesis of estrogenes and of hLH in women. In men the gonadotropins hFSH and hLH stimulate the spermatogenesis and the synthesis of testosterone.
Elevated titers of hFSH point to primary gonadal defects (Ullrich-Turner-Syndrome, Klinefelter-Syndrome), primary testicular malfunctions, selective functional impairments of the Sertoli cells, exhaustion of the ovaries (Climacterium praecox, postmenopause), or to ovarial insufficiency (primary amenorrhoea).
A reduced secretion of the gonadotropins hFSH and hLH may be caused by damages of the pituitary (infarctions, traumata, tumors) or by functional impairments of the hypothalamus and manifest itself by secondary amenorrhoea and secondary testicular malfunctions.
Fields of application
The FSH Serum ELISA from BIOSERV Diagnostics can be applied in the clinical practice for
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the diagnosis of primary and secondary amenorrhoea
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the diagnosis of menstrual cycles occuring without ovulation
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investigations within the scope of the treatment of female infertility
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the confirmation of premature climacterium
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the detection of a primary testicular malfunction in men
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investigations within the scope of the treatment of male infertility
Sample material: serum
Reference value range for the hFSH concentration in serum (reference: 2.IRP 78/549)
|
Women |
|
|
Follicular phase |
2-10 mIU/ml |
|
Ovulation |
7-20 mIU/ml |
|
Luteal phase |
2-10 mIU/ml |
|
Women after the menopause |
20-100 mIU/ml |
|
Men |
2-10 mIU/ml |
For further information please send us an e-mail: info@bioserv-diagnostics.com
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