Risk Pregnancy Monitoring

Ready-to-use diagnostic kits from BIOSERV Diagnostics for the monitoring of risk pregnancies

Pathological immune responses jeopardize embryogenesis and represent a tremendous risk factor during pregnancy. 

To monitor risk pregnancies BIOSERV has developed different test systems detecting parameters of relevance such as the insulin-like-growth-factor binding protein-1 (IGFBP-1, pp12) and glycodelin (pp14).



IGFBP-1 (placenta protein pp12) ELISA

(Insulin-like growth factor binding protein-1, placenta protein 12, pp 12, BP-25, a1-pregnancy associated endometrial globulin, alpha1-PEG or a1-PEG, somatomedins-binding protein)


For a prognosis on the fetal, embryonic and postnatal development. The IGFBP-1 level in maternal serum during the 3rd trimester of pregnancy correlates inversely proportionally with the weight of the placenta and the later birthweight. Within the first 3 months of life IGFBP-1 concentrations in the plasma are significantly reduced compared to values measured in the umbilical cord. Children with stunted growth show higher average values of IGFBP-1 than children of normal growth. But growth disorders will only occur if high levels of IGFBP-1 are not reduced quickly after birth, turning this protein into a good postnatal indicator for child-growth disorders.

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Glycodelin (placenta protein 14, pp14) ELISA

(also referred to as placenta protein14 (pp14), alpha2-uterus protein)


Low levels of glycodelin both in men and women causally indicate potentially jeopardized pregnancies. Glycodelin is a glycoprotein revealing strong immunosuppressive and contraceptive properties. If concentrations in the female serum are too low, immunological rejections against the embryo could take place. In the female organism semen always acts as an antigen. In order to suppress the local immune response spermatozoa are always introduced into the feminine genital organs in combination with glycodelin (pp14). Having a strong immunosuppressive effect, Glycodelin inhibits a local immune response. Therefore, if glycodelin concentration in seminal fluid is too low, pathological anti-sperm antibodies in the female genitalia may be the result.

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