Glycodelin (placenta protein 14, pp14) ELISA


also referred to as placenta protein14 (pp14), alpha2-uterus protein


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Shelf Life:
12 months after date of manufacture

Importance in the clinical routine for: Gynaecologists, Andrologists, Urologists

The BIOSERV Diagnostics ELISA for the determination of Glycodelin (pp14, placenta protein 14) was designed for the quantitative determination of gycodelin

  • in female serum in order to predict a possible allogeneic rejection response and consequently infertility or miscarriage
  • in male seminal plasma in order to predict insemination problems because of a too low concentration


To order the test please refer to the BIOSERV catalogue number BS-30-20


Principle of the test

Glycodelin levels are quantitatively determined in human sample materials such as serum and seminal fluid.


This glycodelin-ELISA is based on the sandwich principle using monoclonal anti-glycodelin antibodies of high affinity to determine the glycodelin concentration contained in the sample.


More details on glycodelin

Human glycodelin is a glycoprotein with strong immunosuppressive and contraceptive activities. In women glycodelin is produced and secreted by glandular epithelial cells of the endometrium while in men it is produced in the seminal vesicles. Glycodelin in seminal fluid is immunologically identical to endometrially produced glycodelin but different in glycosylation.


Human glycodelin is considered as a biochemical marker for the course of pregnancy, especially for the glandular epithelium activity at implantation and placentation. Functional evaluation of the endometrium is made possible by measurement of the glycodelin level in serum. Its highest concentration can be found during the first trimester of pregnancy. Women with irregular bleedings and a reduced glycodelin level have a five times higher risk for habitual spontaneous abortions during pregnancy compared to women with regular bleedings and a normal glycodelin level.


The concentration of glycodelin in serum is also an important parameter to monitor the menstruation cycle as it can be used to distinguish between ovulatory cycles and non-ovulatory cycles. Women predisposed for risks of habitual miscarriage during the late luteal phase show lower glycodelin values than normally fertile women. Moreover, glycodelin serum levels of ectopic pregnancies are lower than those found in intrauterine pregnancies. Moreover, a significant difference in concentration between aborts and ectopic pregnancy is detectable, while hCG levels seem to be identical in those cases. The determination of glycodelin levels in sera of pregnant women therefore is of great predictive value for the course of a risk pregnancy. During in-vitro fertilization glycodelin values are significantly increased in twin-pregnancies compared to single-pregnancies.


Glycodelin in seminal fluid (up to 2 % of the total protein) also together with maternal endometrial glycodelin enables implantation and placentation by inhibiting the female immune response against the allogeneic foetus. 


Medical indications for the application of BIOSERV Diagnostics Glycodelin ELISA

  • Women predisposed for a habitual spontaneous abortion
  • Preparation of women for an in-vitro fertilization therapy
  • Suspected male subfertility and infertility


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