Anti-ovary antibody determinations
Importance in the clinical routine for: Gynecologists to diagnose fertility disorders
Around 30% of all infertility cases of unknown etiology originate in an immunopathological response of the female patient. Anti-sperm allo-antibodies prevent the migration of the spermatozoa through the female genital tract while autoantibodies against ovarian tissue (anti-ovary antibodies or ovary antibodies) or zona pellucida antigens (anti-zona pellucida antibodies or zona pellucida antibodies) inhibit egg maturation as well as the binding of or penetration by spermatozoa. Autoantibodies in serum of female patients directed against antigens of ovarian tissue, antiovary antibodies (ovary antibodies), may play a crucial role in female infertility and in the outcome of an assisted reproduction therapy. Usually, the spermatozoa-oocyte-interaction and consequently the fertilization are impaired. Yet antiovary antibodies may also hinder egg maturation and may cause somatopathic disorders in women. Pregnancy rates of these patients with antiovary antibodies are drastically reduced even after an in-vitro fertilization therapy.
BIOSERV Diagnostics offers the following ready-to-use anti-ovary antibody tests:
Anti-ovary antibody ELISA - Ig-classifying (Ig-typing)
Anti-ovary antibody latex agglutination test
Anti-ovary antibody hemagglutination test
For further information please send us an e-mail: info@bioserv-diagnostics.com
EU registration number
DE/CA80/IVD1698
Quantitative ELISA to determine antibodies directed against ovarian antigens.
Principle of the test: Anti-ovary antibodies of the patient’s sample material bind to ovary antigens immobilized on a 96-well-ELISA plate. In the second step enzyme-linked antibodies directed against human immunoglobulins are used. The antibody concentration in the patient's serum correlates directly to the extinction values of the subsequent photometric measurements (450 nm).
Sample materials: Serum
To order the test please refer to the BIOSERV catalogue number BS-40-20.
For further information please send us an e-mail: info@bioserv-diagnostics.com
Anti-ovary antibody ELISA - Ig-classifying (Ig-typing)
EU registration number
DE/CA80/IVD1702
After detection of anti-ovary antibodies, a classification of these immunoglobulins (IgG, IgA, IgM) may be carried out.
Principle of the test: Anti-ovary antibodies of the patient's sample material bind to ovary-antigens immobilized on a 96-well-ELISA plate. In the second step enzyme-linked antibodies directed against human immunoglobulins of the classes IgG, IgM and IgA are used. The antibody concentration in the patient's serum correlates directly to the extinction values of the subsequent photometric measurements at 450 nm.
Sample materials: Serum
To order the test please refer to the BIOSERV catalogue number BS-40-50
For further information please send us an e-mail: info@bioserv-diagnostics.com
Anti-ovary antibody latex
agglutination test
EU registration number
DE/CA80/IVD1707
By means of the ovary antibody latex agglutination test even smallest amounts of serum can be examined for the presence of anti-ovary antibodies.
Principle of
the test:
Only if
antibodies directed against ovarian
antigens
are present in sample materials to be examined, latex particles
being coated with this antigen will agglutinate within 1 - 2 minutes. The test
is carried out on special slides delivered with the kit. All steps are easy to
follow, diagnosis is quickly archived and titer of ZP-antibodies can be
determined afterwards.
Sample materials: Serum
To order the test please refer to the BIOSERV catalogue number BS-40-10
For further information please send us an e-mail: info@bioserv-diagnostics.com
Anti-ovary antibody hemagglutination test
EU registration number
DE/CA80/IVD1710
With this test anti-ovary antibodies possibly responsible for fertility disorders in the serum of subfertile women are diagnosed and the titer is determined.
Principle of the test: This test is based upon specially pretreated and sensitized red blood cells (SRBC) coated with ovarian antigens. Antibodies in the sample agglutinate with coated SRBC within 120 min.
Sample materials: Serum
To order the test please refer to the BIOSERV catalogue number BS-40-30
For further information please send us an e-mail: info@bioserv-diagnostics.com
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